POLIMORFISME GEN PADA PENYAKIT MALARIA

Sri Wahyuni

Abstract


Malaria adalah penyakit infeksi yang disebabkan oleh parasit Plasmodium yang hidup dan berkembang biak dalam sel darah merah manusia. Di Indonesia, malaria masih merupakan salah satu masalah kesehatan masyarakat yang dapat menyebabkan kematian terutama pada kelompok risiko tinggi yaitu bayi, anak balita, ibu hamil. Pengaruh genetik pejamu pada kerentanan terhadap malaria telah banyak diteliti beberapa tahun terakhir. Beberapa faktor genetik merupakan determinan utama bagi child survival di negara endemis malaria. Identifikasi gen yang terlibat dan pengaruhnya terhadap risiko penyakit malaria dapat memberikan suatu pengetahuan mengenai mekanisme untuk mempelajari hubungan pejamu-parasit malaria.


Keywords


malaria, gen, polimorfisme

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References


World Health Organization. World Malaria Report 2012; Geneva.

Departemen Kesehatan RI. Pedoman Penataksanaan Kasus Malaria di Indonesia. Direktorat Jenderal Pengendalian Penyakit dan Penyehatan Lingkungan; 2008.

Williams, T N. Human red blood cell polymorphisms and malaria. Current Opinion in Microbiology 2006; 9:1–7.

Zimmerman PA, Fitness J, Moulds JM, McNamara DT, Kasehagen LJ, Rowe JA, Hill AV: CR1 knops blood group alleles are not associated with severe malaria in the Gambia. Genes Immun 2003; 4:368-373.

Nagayasu E, Ito M, Akaki M, Nakano Y, Kimura M, Looareesuwan S, Aikawa M: CR1 density polymorphism on erythrocytes of falciparum malaria patients in Thailand. Am J Trop Med Hyg 2001; 64:1-5.

Phompradit et al. Prevalence and distribution of glucose-6- phosphate dehydrogenase (G6PD) variants in Thai and Burmese populations in malaria endemic areas of Thailand Malaria. Journal 2011; 10:368.

Weatherall D.J, Clegg J.B.,Genetic variability in response to infection: malaria and after. Genes and Immunity 2002; 3: 331–337.

Driss A, Hibbert JM, Wilson NO, Iqbal SA, Adamkiewicz TV, Stiles JK. Genetic polymorphisms linked to susceptibility to malaria. Malaria J 2011; 10:271

Cavasini CE. Duffy blood group gene polymorphisms among malaria vivax patients in four areas of the Brazilian Amazon region. Malaria Journal 2007; 6:167 doi:10.1186/1475-2875-6-167.

Koukouikila-Koussounda et al., Genetic evidence of regulatory gene variants of the STAT6, IL10R and FOXP3 locus as a susceptibility factor in uncomplicated malaria and parasitaemia in Congolese children. Malaria Journal 2013; 12:9.

Cramer et al., Toll-like receptor (TLR) polymorphisms in African children: Common TLR- 4 variants predispose to severe malaria. J Commun Dis 2006; 38:230-245.

Zakeri S, Pirahmadi S, Mehrizi A.A, Djadid N.D, Genetic variation of TLR-4, TLR-9 and TIRAP genes in Iranian malaria patients. Malaria Journal 2011; 10:77

Greene et al., Toll-like receptor polymorphisms and cerebral malaria: TLR2 Δ22 polymorphism is associated with protection from cerebral malaria in a case control study. Malaria Journal 2012; 11:47.

Esposito et al., Role of polymorphisms of toll-like receptor (TLR) 4, TLR9, toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children. Malaria Journal 2012; 11:196.

Day NP et al., The prognostic and pathophysiologic role of pro- and anti-inflammatory cytokines in severe malaria. J Infect Dis 1999; 180:1288–1297.

Lyke KE et al., Serum levels of the pro inflammatory cytokines interleukin-1 beta (IL-1beta), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with Kementerian Kesehatan RI. Epidemiologi Malaria di Indonesia. Buletin Jendela Data dan Informasi Kesehatan; 2011.

Okeyo et al. Interleukin (IL)-13 promoter polymorphisms (−7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels BMC Immunology 2013; 14:15.




DOI: https://doi.org/10.29103/averrous.v2i1.411

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