STEVENS JOHNSON SYNDROME
Abstract
Stevens Johnson Syndrome (SJS) merupakan suatu sindroma atau kumpulan gejala yang mengenai kulit, selaput lendir, dan mata dengan keadaan umum yang bervariasi dari ringan sampai berat. Penyakit ini bersifat akut dan pada bentuk yang berat dapat menyebabkan kematian, oleh karena itu penyakit ini merupakan salah satu kegawatdaruratan penyakit kulit. Sindroma ini merupakan salah satu contoh immune-complex-mediated hypersensitivity, atau yang juga disebut reaksi hipersensitivitas tipe III, di mana kejadiaannya dapat diinduksi oleh paparan obat, infeksi, imunisasi, maupun akibat paparan fisik lain kepada pasien. Stevens Johnson Syndrome berisiko menimbulkan kematian, perawatan dan pengobatan pasien SJS sangat membutuhkan penanganan yang tepat dan cepat. Adapun terapi yang bisa diberikan antara lain perawatan terhadap kulit dan penggantian cairan tubuh, perawatan terhadap luka, serta perawatan terhadap mata. Kelangsungan hidup pasien Stevens Johnson Syndrome bergantung pada tingkat pengelupasan kulit, di mana apabila pengelupasan kulit semakin meluas, maka prognosisnya dapat menjadi semakin buruk. Selain itu, variabel lain seperti dengan usia penderita, keganasan penyakit tersebut, denyut jantung, kadar glukosa, kadar BUN dan tingkat bikarbonat juga dapat mempengaruhi kelangsungan hidup pasien.
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DOI: https://doi.org/10.29103/averrous.v5i1.1632
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