STEVENS JOHNSON SYNDROME
Abstract
Stevens Johnson Syndrome (SJS) merupakan suatu sindroma atau kumpulan gejala yang mengenai kulit, selaput lendir, dan mata dengan keadaan umum yang bervariasi dari ringan sampai berat. Penyakit ini bersifat akut dan pada bentuk yang berat dapat menyebabkan kematian, oleh karena itu penyakit ini merupakan salah satu kegawatdaruratan penyakit kulit. Sindroma ini merupakan salah satu contoh immune-complex-mediated hypersensitivity, atau yang juga disebut reaksi hipersensitivitas tipe III, di mana kejadiaannya dapat diinduksi oleh paparan obat, infeksi, imunisasi, maupun akibat paparan fisik lain kepada pasien. Stevens Johnson Syndrome berisiko menimbulkan kematian, perawatan dan pengobatan pasien SJS sangat membutuhkan penanganan yang tepat dan cepat. Adapun terapi yang bisa diberikan antara lain perawatan terhadap kulit dan penggantian cairan tubuh, perawatan terhadap luka, serta perawatan terhadap mata. Kelangsungan hidup pasien Stevens Johnson Syndrome bergantung pada tingkat pengelupasan kulit, di mana apabila pengelupasan kulit semakin meluas, maka prognosisnya dapat menjadi semakin buruk. Selain itu, variabel lain seperti dengan usia penderita, keganasan penyakit tersebut, denyut jantung, kadar glukosa, kadar BUN dan tingkat bikarbonat juga dapat mempengaruhi kelangsungan hidup pasien.
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Adithan C. Stevens-Johnson Syndrome. In: Drug Alert. JIPMER. 2006;2(1). India.
Djuanda A. Sindrom Stevens-Johnson. Ilmu Penyakit Kulit dan Kelamin edisi 5. Bagian Ilmu Penyakit Kulit dan Kelamin Fakultas Kedokteran Universitas Indonesia. Balai Penerbit Fakultas Kedokteran Universitas Indonesia. Jakarta. 2007:163-5.
Djuanda A.:”Sindroma Stevens-Johnson”,MDK,vol.9 no.4, Mei 190,halaman 50.
V.K Sharma GGS. Adverse cutaneous reaction to drugs; an overview. J Postgard Med. 1996;42((1))
A Mansjoer S, Wardhani WI, Setiowulan W. Erupsi Alergi Obat.. Kapita Selekta Kedokteran Edisi ketiga Jilid 2. Jakarta: Fakultas Kedokteran Universitas Indonesia. Media Aesculapius; 2000.
Lebargy F, Wolkenstein P, Gisselbrecht M, Lange F, Fleury-Feith J, Delclaux C, Roupie E, Revuz J, Roujeau JC: Pulmonary complications in toxic epidermal necrolysis: a prospective clinical study. Intensive Care Med 1997, 23:1237-1244.
Chang YS, Huang FC, Tseng SH, Hsu CK, Ho CL, Sheu HM: Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis: acute ocular manifestations, causes, and management. Cornea 2007, 26:123-129.
Mockenhaupt M, Messenheimer J, Tennis P, Schlingmann J: Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics. Neurology 2005, 64:1134-1138.)
Roujeau, JC, Chosidow, O, Saiag, P, Guillaume, JC. Toxic epidermal necrolysis (Lyell syndrome). J Am Acad Dermatol 1990; 23:1039
Westly, ED, Wechsler, HL. Toxic epidermal necrolysis. Granulocytic leukopenia as a prognostic indicator. Arch Dermatol 1984; 120:721
R.P Langlais CSM. Colour Atlas of Common Oral Diseases. Philadelpia: Lea &Febiger; 2003
Siregar RS.Sindrom Stevens Johnson. Saripati Penyakit Kulit 2nd edition. Jakarta: EGC; 2004.p. 141-2.
Adithan C. Stevens-Johnson Syndrome. In: Drug Alert. JIPMER. 2006;2(1). India
A Mansjoer S, Wardhani WI, Setiowulan W. Erupsi Alergi Obat. .Kapita Selekta Kedokteran Edisi ketiga Jilid 2. Jakarta: Fakultas Kedokteran Universitas Indonesia. Media Aesculapius; 2000.
NN. Sindrom Steven-Johnson, manifestasi klinis, dan penanganannya. Didapat dari: http://allergycliniconline.com.
Majiid Sumardi. Steven Johnsons Syndrome.
Monica. Sindrom Stevens-Johnson. Didapat dari: http://elib.fk.uwks.ac.id/.
Mockenhaupt M. The current understanding of Stevens-Johnson syndrome and toxic epidermal necrolysis. Expert Review Clinical Immunology. 2011;7(6):803-15.
Foster CS. Stevens-Johnson syndrome. Medscape. 2013. Didapat dari: http://emedicine.medscape.com/.
Mockenhaupt M. The current understanding of Stevens-Johnson syndrome and toxic epidermal necrolysis. Expert Review Clinical Immunology. 2011;7(6):803-15.
Klein PA. Dermatologic manifestation of Stevens-Johnson syndrome and toxic epidermal necrolysis. Medscape. 2013. Didapat dari: http://emedicine.medscape.com/.
Knowles S, Shear NH. Clinical risk management of stevens Johnson syndrome, toxic epidermal necrolysis. Dalam: Spectrum; 2009;22:441-451
Nirken, M. H. dan High, W. A. Stevens-Johnson syndrome and toxic epidermal necrolysis: Clinical manifestations; pathogenesis; and diagnosis. Didapat dari http://nihlibrary.ors.nih.gov/.
Abood Gerard J., Nickoloff Brian J., Gamelli Richard L. 2008. ‘Treatment Strategies in Toxic Epidermal Necrolysis Syndrome: Where Are We At?’ Journal of Burn Care and Research Volume 29, Number1, January/February 2008, American Burn Association. p.272.
Valeyrie Allanore L, Roujeau JC. Epidermal Necrolysis (Steven Johnsosns Syndrome and Toxic Epidermal Necrolysis). Dalam: Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffel DJ, editors. Fitzpatricks Dermatology in General Medicine. 7th ed. New York: Mc Graw;2008;349-55
Milton H. Nirken et all. Steven-Johnson Syndrome and Toxic Epidermal Necrolysis : Pathogenesis, Clinical manifestations and diagnosis, MD Employee of UpToDate Inc , Feb 2015
Harr Thomas, French LE. Toxic epidermal necrolysis and stevens Johnson syndrome. Dalam: Orphanet Journal of rare disease 2010:1-11
Mahadi IDR. Sindroma Stevens Johnson. Dalam: Simposium dan Pelatihan “What’s new in Dermatology”. Banda Aceh, 10 Juli 2010; 1-5
Torres MJ, Mayorga C, Blanca M. Nonimmediate Allergic Reactions Induced by Drugs: Pathogenesis and Diagnostic Test. Dalam: J Investing Allergol Clind Immunol 2009;19:80-90
Maja Mockenhaupt, MD, PhD. The Current Understanding of Steven Johnsos Syndrome and Toxic Epidermal Necrolysis. Expert Rev Clin Immunol 7 (6), 803 – 815 ( 2011 )
Tyagi S, Kumar S, Kumar A, Singla M, Singh A. Stevens Johnson Syndrome-A life threatening disorder: A review. Dalam: J Chem Pharm Res 2010,2(2):618-26
Yim H, Park JM, Suk Kong, Kim D, Hur J, Chun W, et all. A clinical study of stevens Johnson syndrome and toxic epidermal necrolysis: Efficacy of treatment in Burn Intensive care unit. Dalam: J.Korean Surg Soc: 2010(78):133-39
Ho, H. Diagnosis and management of stevens johnsosn syndrome and toxic epidermal necrolysis. Dalam: Hongkong Medical Bulletin;2010 Vol.13 No 10.
Whitney A High, MD et all. Steven Johnson Syndrome and Toxic Epidermal Necrolysis : Management, Prognosis and Long term sequelae. MD Employee of UpToDate Inc, March 2015
Michaels B, Q James. The role of systemic corticosteroid therapy in erythema multiforme major and stevens Johnson syndrome. Dalam: Clinical Aesthetic Dermatology;2009;2:51-55
Widgerow DA. Toxic epidermal necrolysis-management issues and treatment options. Dalam: Int J Burn Trauma; 2011;1(1);42-5
DOI: https://doi.org/10.29103/averrous.v5i1.1632
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