Clinical Benefits of Ketorolac in Postoperative Pain Control Management: A Comprehensive Review

Tjandrakirana M Sjaifullah Noer, Florence Pribadi, Aldy Dion

Abstract


Pain accounts for about 70% of visits to emergency rooms, approximately 80% of surgical patients experience acute postoperative pain, more than 38% of patients are readmitted following surgery due to severe pain. Up to 77% of post surgical patients received insufficient pain treatment, following treatment 71% of patients reported continuing to experience pain and 80% said they were still experiencing moderate to severe pain. Previous studies conducted both domestically and internationally have demonstrated the benefits of ketorolac and its usefulness in managing postoperative pain. This article's goal is to provide a comprehensive understanding of the potential of ketorolac as a pharmacological agent in the management of post-operative pain. A narrative review method was employed, utilizing research articles and international guidelines to gather literature. Around 230 libraries were found to meet the criteria and studied, 27 libraries were used in order to create this article. Ketorolac has a good safety profile and there are a few contraindications in patients that clinicians must be aware. Studies suggest that administering ketorolac within two hours after surgery for a treatment duration of two to five days. Numerous studies have demonstrated the potential of ketorolac in the therapy of postoperative pain.

Keywords


ketorolac, postoperative pain, pain control, narrative review, pain management

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References


Raja S, Carr D, Cohen M, Finnerup N, Flor H, Gibson S. The Revised IASP definition of pain: concepts, challenges, and compromises. Pain [revista en Internet] 2021 [acceso 4 de marzo de 2022]; 161(9): 1-16. Pain [Internet]. 2021;161(9):1976–82.

McNicol ED RE, Cooper TE. Ketorolac for postoperative pain in children. Cochrane Database Syst Rev [Internet]. 2018;(7).

Castroman P, Quiroga O, Mayoral Rojals V, Gómez M, Moka E, Pergolizzi Jr J, et al. Reimagining How We Treat Acute Pain: A Narrative Review. Cureus. 2022;14(4).

Kunstman JW, Brandt WS, Azar SA, Jean RA, Salem RR. Comprehensive Analysis of the Effect of Ketorolac Administration after Pancreaticoduodenectomy. J Am Coll Surg [Internet]. 2020;230(6):935-942.e2.

Alit K, Wiguna A, Ngurah IG, Aribawa M, Wayan I, Agung G, et al. Gambaran Intensitas Nyeri Pasien Pasca Operasi Abdomen Bawah di RSUP Sanglah. J Med Udayana. 2021;10(8):4–8.

Lubis KA, Sitepu JF. Angka Kejadian Nyeri Pasca Operasi Kebidanan Di Rumah Sakit Umum Delima Medan Sumatera Utara Tahun 2020. J Kedokt Ibnu Nafis. 2021;10(2):110–5.

Saragih IS, Rupang E, Tampubolon L, Ginting A, Simorangkir L. Correlation of Pain Intensity and Pain Interference in Post Operation Patients. Indones J Glob Heal Res [Internet]. 2022;4(4):759.

Zimmer Z, Fraser K, Grol-Prokopczyk H, Zajacova A. A global study of pain prevalence across 52 countries: examining the role of country-level contextual factors. Pain. 2022 Sep;163(9):1740–50.

Zhang X, Chang J, Ran R, Xiao Y, Cao H, Wang Y. Effect of Ketorolac Tromethamine Combined With Remifentanil on Reducing Complications During the General Anesthesia Emergence. J Perianesthesia Nurs [Internet]. 2023;38(5):748–52.

Yusuke Mazda, Sandra Jadin, James S. Khan. Postoperative Pain Management. Can J Gen Intern Med. 2021;16(1):5–17.

Mahmoodi AN, Kim PY. Ketorolac. In Treasure Island (FL); 2023.

Hudson LG, Cook LS, Grimes MM, Muller CY, Adams SF, Wandinger-Ness A. Dual Actions of Ketorolac in Metastatic Ovarian Cancer. Cancers (Basel) [Internet]. 2019;11(8).

HIĽOVSKÁ L, JENDŽELOVSKÝ R, FEDOROČKO P. Potency of non-steroidal anti-inflammatory drugs in chemotherapy. Mol Clin Oncol. 2015;3(1):3–12.

MIMS. Ketorolac [Internet]. 2023. p. Available from: https://www.mims.com/indonesia/drug/info/ketorolac?mtype=generic

McDonald EL, Daniel JN, Rogero RG, Shakked RJ, Nicholson K, Pedowitz DI, et al. How Does Perioperative Ketorolac Affect Opioid Consumption and Pain Management After Ankle Fracture Surgery? Clin Orthop Relat Res. 2020 Jan;478(1):144–51.

Eftekharian HR, Ilkhani Pak H. Effect of Intravenous Ketorolac on Postoperative Pain in Mandibular Fracture Surgery; A Randomized, Double-Blind, Placebo-Controlled Trial. Bull Emerg trauma [Internet]. 2017;5(1):13–7.

Stone SB. Ketorolac in Postoperative Neonates and Infants: A Systematic Review. J Pediatr Pharmacol Ther [Internet]. 2021 Mar 31;26(3):240–7.

Javaherforooshzadeh F, Abdalbeygi H, Janatmakan F, Gholizadeh B. Comparing the effects of ketorolac and Paracetamol on postoperative pain relief after coronary artery bypass graft surgery. A randomized clinical trial. J Cardiothorac Surg. 2020;15(1):1–8.

Gopalraju P, Lalitha RM, Prasad K, Ranganath K. Comparative study of intravenous Tramadol versus Ketorolac for preventing postoperative pain after third molar surgery - A prospective randomized study. J Cranio-Maxillofacial Surg [Internet]. 2014;42(5):629–33.

Dwarica DS, Pickett SD, Zhao YD, Nihira MA, Quiroz LH. Comparing Ketorolac With Ibuprofen for Postoperative Pain: A Randomized Clinical Trial. Urogynecology [Internet]. 2020;26(4).

Anand A, Sprenker CJ, Karlnoski R, Norman J, Miladinovic B, Wilburn B, et al. Intravenous acetaminophen vs. ketorolac for postoperative analgesia after ambulatory parathyroidectomy. Scand J Pain [Internet]. 2013;4(4):249–53.

Furdiyanti NH, Oktianti DO, Rahmadi RR, Coreira LC. Keefektifan Ketoprofen Dan Ketorolak Sebagai Analgesik Pada Pasien Pasca Bedah Cesar. Indones J Pharm Nat Prod. 2019;2(1).

McDonald E, Winters B, Nicholson K, Shakked R, Raikin S, Pedowitz DI, et al. Effect of Postoperative Ketorolac Administration on Bone Healing in Ankle Fracture Surgery. Foot & Ankle Int [Internet]. 2018;39(10):1135–40.

Maslin B, Lipana L, Roth B, Kodumudi G, Vadivelu N. Safety Considerations in the Use of Ketorolac for Postoperative Pain. Curr Drug Saf. 2017;12(1):67–73.

Song H, Li C, Qu C, Zhang Y, Miao S. Clinical research for dose effects of ketorolac tromethamine on PCIA after hip arthroplasty. Food Sci Technol. 2022;42:1–5.

Vadivelu N, Gowda AM, Urman RD, Jolly S, Kodumudi V, Maria M, et al. Ketorolac Tromethamine – Routes and Clinical Implications. Pain Pract [Internet]. 2015;15(2):175–93.

Lyon C, Claus LW, Jarrett JB, Stevermer JJ. Less is more when it comes to ketorolac for pain. J Fam Pract. 2019;68(1):41–2.




DOI: https://doi.org/10.29103/averrous.v10i1.14909

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