PERANAN PROTEIN ADHESI MATRIKS EKSTRASELULAR DALAM PATOGENITAS BAKTERI STAPHYLOCOCCUS AUREUS
Abstract
Bakteri Staphylococcus merupakan salah satu bakteri yang sering menimbulkan infeksi pada manusia.Beberapa spesiesnya merupakan flora normal pada kulit dan selaput lendir manusia, ada yang bersifat patogen yang dapat menyebabkan infeksi piogenik bahkan septikemia. Staphylococcus aureus merupakan spesies yang paling invasif. Bakteri ini memiliki beragam faktor virulensi, yang mencakup protein-protein permukaan yang berperan dalam perlekatan kuman, enzim-enzim yang menguraikan protein, dan toksin yang merusak sel penjamu. Faktor virulensi S. aureus saling mempengaruhi, dengan struktur dan sekresi produknya yang berperan dalam patogenesis infeksi. Banyak faktor yang berperan dalam patogenitas bakteri Staphylococcus aureus, mulai dari metabolit bakteri, faktor virulensi sampai perananprotein adhesi matriks ekstraseluler.
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Beckers WM, Kleinsmith LJ ,Hardin J.,Gregory Bertoni, Lewis J.. 2006. Cell-Cell Recognition and Adhesion, inBecker’s World of the Cell. Eight eds. Pearson’s. San Fransisco : Benjamin Cummings, Inc. Pp ; 477-483
Berendt, A. R. & McCormick, C. J. (1997).Use of host adhesionmolecules by infectious agents. InAdhesion Molecules in Healthand Disease, 1st edn, pp. 347±379. Edited by L. C. Paul & T. B.Issekutz. New York : Marcel Dekker.
Brooks, Geo, F., Janet S. Butel, Stephen A. Morse, 2005. Staphylococcus, medical microbiology jawetz, melnick, & Alderberg’s, buku 1. Jakarta : Penerbit Salemba Medika ; 317- 326
Communicable Disease Surveillance Centre (1998).Bacteraemia and bacterial meningitis, England and Wales. Commun Dis RepCDR Wkly 9, 254.
Emori, T. G. & Gaynes, R. P. (1993).An overview of nosocomial, infections, including the role of the microbiology laboratory.ClinMicrobiol Rev 6, 428±442.
Foster TJ, Hook M. 1998. Surface protein adhesins of Staphylococcus aureus. Trends Microbiol ;6:484-8. CrossRefMedlineWeb of Science.
Foster, T. J. & McDevitt, D. (1994).Surface-associated proteins of Staphylococcus aureus: their possible roles in virulence. FEMS Microbiol Lett 118, 199±206.
Freter, R. and G.W. Jones. 1983. Models for Studying the Role of Bacterial attachment inVirulence and Pathogenesis. Rev. Inf. Dis 5. pp 647-658
Gillespie, Stephen and Kathleen Bamford. 2009. Staphylococcus, Patogenesesis Penyakit Infeksi dalam At a Glance Mikrobiologi Medis Dan Infeksi, edisi ketiga. Jakarta : penerbit Erlangga ; 32-33, 12-14, 1.
Jaffe, E. A. & Mosher, D. F. 1978. Synthesis of fibronectin by cultured human endothelial cells. J Exp Med 147, 1779±1791.
Kleinsmith LJ, Kish VM, 1995. Principles of Cell and Molecular Biology. New York : HarperCollins College Publisher.
Kumar, Abbas, Faustro. 2010. Dasar Patologis Penyakit Robins & Cotrans, edisi 7. Jakarta : Penerbit EGC.
Ljungh, A, S. Hjerten and T. Wadström. 1985. High surface hydrophobicity of autoaggregating Staphylococcus aureusstrains isolated from human infections studied with the salt aggregation test. Infect. Immun. 47(2): 522-526.
Lowy FD. 1998.Staphylococcus aureus infections. N Engl J Med ;339:520-32.CrossRefMedlineWeb of Science.
McCormick JK, Yarwood JM, Schlievert PM. Toxic shock syndrome and bacterial superantigens: an update. Annu Rev Microbiol 2001;55:77-104. CrossRefMedlineWeb of Science.
Murray RK, Granner DK, Rodwell VW, 2006. Biokimia Harper. Edisi 27. Alih Bahasa: Brahm U. Pendit. Jakarta: EGC.
Nasronuddin, Suharto, dkk, 2007. Penatalaksanaan Infeksi Berat Akibat Bakteri, dalam Penyakit Infeksi di Indonesia, Solusi Kini dan Mendatang. Surabaya : penerbit Airlangga University Press ; 220-221.
Ozeri, V., Rosenshine, I., Mosher, D. F., Fassler, R. & Hanski, E. 1998. Roles of integrins and Fibronectin in the entry ofStreptococcus pyogenes into cells via protein F1. Mol Microbiol 30, 625±637.
Pankov R, Yamada KM (October 2002). "Fibronectin at a glance". Journal of Cell Science115 (Pt 20): 3861–3.
Patti JM, Allen BL, McGavin MJ, Hook M. 1994. MSCRAMM-mediated adherence of microorganisms to host tissues. Annu Rev Microbiol ;48:585-617.MedlineWeb of Science
Pelczar, M.J. and E.C.S. 2006. Dasar-dasarMikrobiologi. (Translated by Hadioetomo,
R.S) Penerbit Universitas Indonesia Press.Jakarta.
Rachel J. Gordon1 and Franklin D. Lowy. 2008. Pathogenesis of Methicillin-Resistant Staphylococcus aureus Infection in Clinical Infectious Diseases, Oxford Journals, Volume 46, Issue Supplement 5
Radji, Maksum. 2011. Bakteri Patogen pada Kulit dan Mata, dalam buku ajar mikrobiologi panduan mahasiswa farmasi dan kedokteran. Jakarta : Penerbit EGC ; 179-189.
Raja, R. H., Raucci, G. & Hook, M. 1990.Peptide analogues to a Fibronectin receptor inhibit attachment of Staphylococcus aureus to Fibronectin-coated surfaces. Infect Immun
Roitt IM, 2003. Pengenalan antigen.In : Essential Immunology, 8th eds. Jakarta : Widya Medika ; 93-94.
Shulmann, Stanford T., John P. Phair, Herbert M. Sommers.1994. Stafilokokus, Penyakit Stafilokokus dan Sindrom shok toksik dalam buku dasar biologis dan klinis penyakit infeksi, edisi keempat. Yogyakarta : penerbit Gajah Mada University Press ; 550-557.
Smith, T.H, 1984. The Biochemical challenge ofmicrobial pathogenicity. J. Appl. Bact.
:395-404.
Suarsana, N.I. 2002. Protein A : Peranannya dalam mekanisme infeksi. J. Vet. 2002 3 (1) : 37-43
Todar, kenneth. 2009. Staphylococcus and staphylococcal Disease. The microbial world htm.
Vercellotti, GM, Lussenhop, D, Peterson, PK. Bacterial adherence to fibronectin and endothelial cells: a possible mechanism for bacterial tissue tropism. J Lab Clin Med. 1984;103:34–43.
Waldvogel, F. A. 1995. Staphylococcus aureus (including toxic shock syndrome). In Mandell, Douglas and Bennett's Principlesand Practice of Infectious Diseases, 4th edn, vol. 2, pp. 1754±1777.Edited by G. L. Mandell, J. E. Bennett & R. Dolins. New York: Churchill Livingstone.
DOI: https://doi.org/10.29103/averrous.v4i2.1041
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