Syndrome of Inappropriate Antidiuretic Hormone (Siadh) in Lung Cancer

Novita Andayani, Cut Asmaul Husna

Abstract


Lung cancer is one of the deadliest cancers in both men and women. Lung cancer is generally divided into 2, categories: small-cell lung carcinoma and non-small-cell lung carcinoma. Small cell lung carcinoma (SCLC) represents approximately 15% of all lung cancers. Paraneoplastic syndromes occur in 10% of lung cancer cases and constitute a group of disorders associated with the secretion of functional polypeptides or hormones from tumor cells. The syndrome of inappropriate antidiuretic hormone is a paraneoplastic syndrome that is closely related to SCLC and is associated with worse survival. The key to understanding SIADH is that the hyponatremia that occurs in this syndrome is not caused by Na+ deficiency but rather by excess fluid. The syndrome of inappropriate antidiuretic hormone that occurs is a secondary event caused by the release of antidiuretic hormone due to tumor lysis or because the tumor releases ectopic ADH. Hyponatremia in SCLC is a negative prognostic factor in hospitalized patients and patients with advanced disease


Keywords


lung cancer; small-cell lung carcinoma (sclc); syndrome of inappropriate antidiuretic hormone; hyponatremia; patient

Full Text:

PDF

References


Siegel R, Ma J, Zou Z, et al. Cancer statistics. CA Cancer J Clin. 2014;64(1):9–29.

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;0(0):1–41.

Kalemkerian GP. Staging and imaging of small cell lung cancer. Cancer Imaging (2011) 11, International Cancer Imaging Society

Govindan R, Page N, Morgensztern D, et al. Cancer statistics, 2012. CA Cancer J Clin. 2012;62(1):10–29.

Kanaji N, Watanabe N, et al. Paraneoplastic syndromes associated with lung cancer. WJCO 5th Anniv Special Issues (1): Lung cancer. 2014

Tas D. Paraneoplastic Syndromes in Lung Cancer. Lung Cancer - Strategi DiagnosisTreat. 2018. http://dx.doi.org/10.5772/intechopen.79127

Fiordoliva I, Meletani T, Baleani MG, et al. Managing hyponatremia in lung cancer: latest evidence and clinical implications. Ther Adv Med Oncol. 2017;1–9.

Kalemkerian GP, Akerley W, Bogner P, et al. Small Cell Lung Cancer. J Natl Compr Canc Netw. 2013;11(1):78–98.

Rudin MC, Brambilla E, et al. Small-cell lung cancer. Nature Reviews Disease Primers vol. 7, no: 3. 2021

Fishman JA, Grippi MA, Kotloff RM et al. Fishman’s Pulmonary Disease and Disorders Fifth Edition. New York: Elsevier Saunder; 2015.

Patterson GA, Copper JD, et al. Pearson’s Thoracic & Esophageal Surgery, 3rd edition.Vol. 2 Esophageal. 2008. Elsevier

Cuesta M, Thomson CJ. The syndrome of inappropriate antidiuresis (SIAD). Best Pr Res Clin Endocrinol Metab. 2016;30(2):175–87.

Kanaji N. Prognosis of Patients with Paraneoplastic Syndromes Associated 22 with Lung Cancer. Austin J Pulm Respir Med. 2014;1(2):3–5.

Kotoulas C, Panagiotou I, Tsipas P, et al. Inappropriate antidiuretic hormone secretiondue to squamous cell lung cancer. Asian Cardiovasc Thorac Ann. 2014;0(0):1–3.

Yasir M, Mechanic OJ. Syndrome of Inappropriate Antidiuretic Hormone Secretion.StatPearls Publ [Internet]. 2020; Availablefrom:https://www.ncbi.nlm.nih.gov/books/NBK507777/22.

Mentrasti G, Scortichini L, Torniai M, et al. Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): Optimal Management. Ther Clin Risk Manag.2020;16:663–72.

McDonald P, Lane C, Rojas GE, et al. SIADH in non-small cell lung carcinoma: a case report. Ecancermedicalscience. 2012;6:279

Kotoulas C, Panagiotou I, Tsipas P, et al. Inappropriate antidiuretic hormone secretion due to squamous cell lung cancer. Asian Cardiovasc Thorac Ann. 2014;0(0):1–3.

Iyer P, Ibrahim M, Siddiqui W, et al. Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) as an initial presenting sign of non small cell lung cancercase. report and literature review. Respir Med Case Rep. 2017;22:164–7.

Sherwood L. Fisiologi Manusia: dari sel ke sistem. 6th ed. Jakarta: EGC; 2011.

Guyton AC; Hall JE. Buku ajar fisiologi kedokteran. Jakarta: EGC; 2016.

Castillo JJ, Glezerman IG, Boklage SH, et al. The occurrence of hyponatremia and itsimportance as a prognostic factor in a cross-section of cancer patients. BMC Cancer.2016;31:28–32.

Mansoor SE, Kagen DI, Kansagara D. Case Report: Hyponatremia of malignancy –An alternative mechanism? Syndrome of inappropriate atrial natriuretic peptide (SIANP). F1000 Res. 2014;3:194

Fiordoliva I, Meletani T, Baleani MG, et al. Managing hyponatremia in lung cancer:latest evidence and clinical implications. Ther Adv Med Oncol. 2017;1–9.

Elhassan EA, Schrier RW. Hyponatremia: diagnosis, complications, and management including V2 receptor antagonists. Curr Opin Nephrol Hypertens. 2011;20(2):161–8.

Vecchis RD, Cantatrione C, Mazzei D, Baldi C, Vasopressin Receptor Antagonists for the Correction of Hyponatremia in Chronic Heart Failure: An Underutilized Therapeutic Option in Current Clinical Practice?. J. Clin. Med. 2016, 5, 86;doi:10.3390/jcm5100086 www.mdpi.com/journal/jcm

Castillo Jj, Vincent Ma, Justice E. Diagnosis and Management of Hyponatremia in Cancer Patients . The Oncologist 2012;17:756–765 www.TheOncologist.com

Cairo MS, Bishop M. Tumour lysis syndrome: new therapeutic strategies and classification. Br J Haematol. 2004;127(1):3–11.

Miell J,Dhanjal P, Jamookeeah C. Evidence for the use of demeclocycline in the treatment of hyponatraemia secondary to SIADH: a systematic review. International Journal of Clinical Practice Published by John Wiley & Sons Ltd. Int J Clin Pract, December 2015, 69, 12, 1396–1417




DOI: https://doi.org/10.29103/averrous.v9i2.10719

Article Metrics

 Abstract Views : 172 times
 PDF Downloaded : 3 times

Refbacks

  • There are currently no refbacks.


Copyright (c) 2023 cut asmaul husna

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.


Print ISSN :
2477-5231
Online  ISSN
:
2502-8715

Publisher:
Unimal Logo

Fakultas Kedokteran Universitas Malikussaleh
Kampus Fakultas Kedokteran Universitas Malikussaleh, Jl. Meunasah, Uteunkot Cunda, Lhokseumawe, 24351, Provinsi Aceh, Tel/fax : 081376575984, Email: averrous@unimal.ac.id

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.