Defisiensi Besi dan Anemia Defisiensi Besi: Updated Literature Review
Abstract
Anemia defisiensi besi (ADB) adalah masalah kesehatan global yang mempengaruhi semua usia dan seringkali merupakan komorbiditas umum dalam berbagai kondisi medis. Penyebabnya bervariasi dan berkaitan dengan beberapa faktor risiko yang mengurangi asupan dan penyerapan zat besi atau meningkatkan kebutuhan dan kehilangan zat besi. Meskipun gejala yang muncul mungkin tidak spesifik, efek merugikan dari ADB terjadi pada beberapa kondisi medis. Peningkatan kesadaran tentang prevalensi anemia dapat membantu deteksi dini dan pencegahan ADB. Diagnosis dapat dengan mudah dilakukan dengan pengukuran kadar hemoglobin dan feritin serum. Suplementasi zat besi oral dan intravena perlu dipertimbangkan untuk tatalaksana ADB sesuai indikasi. Literature review ini bertujuan memberikan informasi terbaru dan panduan mengenai diagnosis dan penatalaksanaan anemia defisiensi besi.
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Mark PW. Anemia: Clinical Approach. In: Lazarus HM, Schmaier AH, editors. Concise Guide To Hematology. 2nd ed. Springer Nature Switzerland AG; 2019.
WHO. Accelerating anaemia reduction A comprehensive framework for action. Geneva, Switzerland; 2023 May.
Kassebaum NJ, Jasrasaria R, Naghavi M, Wulf SK, Johns N, Lozano R, et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood. 2014;123:615–24.
Kassebaum NJ. The Global Burden of Anemia. Hematol Oncol Clin N Am. 2015;30:247–308.
WHO. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Geneva, Switzerland; 2011.
Stevens GA, Paciorek CJ, Flores-Urrutia MC, Borghi E, Namaste S, Wirth JP, et al. National, regional, and global estimates of anaemia by severity in women and children for 2000–19: a pooled analysis of population-representative data. Lancet Glob Health. Elsevier Ltd; 2022;10:e627–39.
Nemeth E, Ganz T. Hepcidin-ferroportin interaction controls systemic iron homeostasis. Int J Mol Sci. MDPI; 2021;22.
Dev S, Babitt JL. Overview of iron metabolism in health and disease. Hemodialysis International. Blackwell Publishing Inc.; 2017. page S6–20.
Sukhbaatar N, Weichhart T. Iron regulation: Macrophages in control. Pharmaceuticals. MDPI AG; 2018.
Pantopoulos K, Porwal SK, Tartakoff A, Devireddy L. Mechanisms of mammalian iron homeostasis. Biochemistry. 2012. page 5705–24.
Scientific Advisory Committee on Nutrition. Iron and health . London: The Stationery Office; 2010. Available from: https://assets. publishing.service.gov.uk/government/uploads/system/uploads/ attachment_data/file/339309/SACN_Iron_and_Health_Report.pdf
Yiannikourides A, Latunde-Dada G. A Short Review of Iron Metabolism and Pathophysiology of Iron Disorders. Medicines. MDPI AG; 2019;6:85.
Hentze MW, Muckenthaler MU, Andrews NC. Balancing Acts: Molecular Control of Mammalian Iron Metabolism. Cell. 2004;117:285–97.
Anderson GJ, Frazer DM. Current understanding of iron homeostasis. American J Clin Nutr. 2017;106:1559S-1566S.
Besarab A, Hemmerich S. Iron-Deficiency Anemia. Management of Anemia. New York, NY: Springer New York; 2018. page 11–29.
Camaschella C. New insights into iron deficiency and iron deficiency anemia. Blood Rev. Churchill Livingstone; 2017;31:225–33.
Pasricha SR, Tye-Din J, Muckenthaler MU, Swinkels DW. Iron deficiency. The Lancet. Lancet Publishing Group; 2021;397:233–48.
Camaschella C. Iron deficiency. Blood. 2019;133:30–40.
Camaschella C. Iron deficiency: new insights into diagnosis and treatment. American Society of Hematology. 2015;1–13.
Lopez A, Cacoub P, Macdougall IC, Peyrin-Biroulet L. Iron deficiency anaemia. The Lancet. Lancet Publishing Group; 2016. page 907–16.
Muhsen K, Cohen D. Helicobacter pylori Infection and Iron Stores: A Systematic Review and Meta-analysis. Helicobacter. 2008;13:323–40.
De Falco L, Sanchez M, Silvestri L, Kannengiesser C, Muckenthaler MU, Iolascon A, et al. Iron refractory iron deficiency anemia. Haematologica. 2013. page 845–53.
Soppi E. Iron Deficiency Without Anemia – Common, Important, Neglected. Clin Case Rep Rev. Open Access Text Pvt, Ltd.; 2019;5.
Andro M, Le Squere P, Estivin S, Gentric A. Anaemia and cognitive performances in the elderly: a systematic review. Eur J Neurol. John Wiley & Sons, Ltd; 2013;20:1234–40.
Samson KLI, Fischer JAJ, Roche ML. Iron Status, Anemia, and Iron Interventions and Their Associations with Cognitive and Academic Performance in Adolescents: A Systematic Review. Nutrients. MDPI; 2022;14.
Musallam KM, Taher AT. Iron deficiency beyond erythropoiesis: should we be concerned? Curr Med Res Opin. Taylor & Francis; 2018;34:81–93.
Cappellini MD, Musallam KM, Taher & AT. Iron deficiency anaemia revisited. J Intern Med. 2020;287:153–70.
Lichtman M, Kaushansky K, T. Prchal J, Levi M, Burns L, Linch D. Williams Manual of Hematology. 10th Ed. London, United Kingdom: Mc Graw Hill; 2022.
Snook J, Bhala N, Beales ILP, Cannings D, Kightley C, Logan RPH, et al. British Society of Gastroenterology guidelines for the management of iron deficiency anaemia in adults. Gut. BMJ Publishing Group; 2021;70:2030–51.
WHO. The Global Prevalence Of Anaemia In 2011. Geneva, Switzerland; 2015 Sep.
Melicine S, Peoch K, Ducastel M. Exploration of iron metabolism: what is new? J Lab Precis Med. AME Publishing Company; 2021;6.
Punnonen K, Irjala K, Rajamä A. Serum Transferrin Receptor and Its Ratio to Serum Ferritin in the Diagnosis of Iron Deficiency. Blood. 1997;89:1052–7.
Infusino I, Braga F, Dolci A, Panteghini M. Soluble transferrin receptor (sTfR) and sTfR/log ferritin index for the diagnosis of iron-deficiency anemia: A meta-analysis. Am J Clin Pathol. 2012;138:642–9.
Girelli D, Nemeth E, Swinkels DW. Hepcidin in the diagnosis of iron disorders. Blood. 2016;127:2809–13.
Santiago P. Ferrous versus ferric oral iron formulations for the treatment of iron deficiency: a clinical overview. The Scientific World Journal. Hindawi; 2012;2012.
Tolkien Z, Stecher L, Mander AP, Pereira DIA, Powell JJ. Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis. PLoS One. Public Library of Science San Francisco, CA USA; 2015;10:e0117383.
WebMD. Ferrous Sulfate Tablet, Delayed Release (Enteric Coated) - Uses, Side Effects, and More . 2024 [cited 2024 Apr 18]. Available from: https://www.webmd.com/drugs/2/drug-4127/ferrous-sulfate-oral/details
Muñoz M, Gómez-Ramírez S, Bhandari S. The safety of available treatment options for iron-deficiency anemia. Expert Opin Drug Saf. Taylor & Francis; 2018;17:149–59.
Kumar A, Sharma E, Marley A, Samaan MA, Brookes MJ. Iron deficiency anaemia: Pathophysiology, assessment, practical management. BMJ Open Gastroenterol. BMJ Publishing Group; 2022;9.
DOI: https://doi.org/10.29103/jkkmm.v3i3.16263
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