Penggunaan Kalsineurin Inhibitor Topikal pada Dermatitis Atopik

Aji Prima Putra, Wizar Putri Mellaratna

Abstract


Kalsineurin inhibitor topikal dengan cepat menjadi alternatif populer untuk kortikosteroid topikal dalam mengobati Dermatitis Atopik (DA). Kalsineurin inhibitor topikal, tacrolimus dan pimecrolimus telah disetujui FDA AS untuk pengobatan DA pada pasien yang tidak responsif, tidak toleran, atau tidak cocok untuk terapi kortikosteroid topikal. Disamping besarnya manfaat dan efek samping, belum ada penelitian yang mendukung penggunaak kalsineurin inhibitor sebagai lini pertama pengobatan dermatitis atopi.

Keywords


penghambat kalsineurin; dermatitis atopik

Full Text:

PDF

References


Mandlik DS, Mandlik SK. Atopic dermatitis : new insight into the etiology , pathogenesis , diagnosis and novel treatment strategies. Immunopharmacol Immunotoxicol [Internet]. 2021;43(2):105–25. Available from: https://doi.org/10.1080/08923973.2021.1889583

Carr warner W. Topical Calcineurin Inhibitors for Atopic Dermatitis : Review and Treatment Recommendations. Pediatr Drugs. 2013;15:303–10.

Umar BU, Rahman S, Dutta S, Islam T, Nusrat N, Farizatul W, et al. Management of Atopic Dermatitis : The Role of Tacrolimus. 2022;14(8).

Siegfried EC, Jaworski JC, Kaiser JD, Hebert AA. Systematic review of published trials : long- term safety of topical corticosteroids and topical calcineurin inhibitors in pediatric patients with atopic dermatitis. BMC Pediatr [Internet]. 2016;1–15. Available from: http://dx.doi.org/10.1186/s12887-016-0607-9

Guenther L, Lynde C, Poulin Y. Off-Label Use of Topical Calcineurin Inhibitors in Dermatologic Disorders. J Cutan Med Surg. 2019;23(4_suppl):27S-34S.

Alomar A, Bos JD, Giannetti A, Reitamo S, Group W, Atopic ON. The role of topical calcineurin inhibitors in atopic dermatitis : 2004;151:3–27.

Fiorillo L, Marcoux D, Ramien M. Contemporary Role of Topical Calcineurin Inhibitors: A Pediatric Dermatology Perspective. J Cutan Med Surg. 2019;23(4_suppl):11S-18S.

Luger T, Paul C. Potential new indications of topical calcineurin inhibitors. Dermatology. 2007;215 Suppl 1:45–54.

Frankel HC, Qureshi AA. Comparative Effectiveness of Topical Calcineurin Inhibitors in Adult Patients with Atopic Dermatitis. 2012;13(2):113–23.

El-Batawy MMY, Bosseila MA-W, Mashaly HM, Hafez VSGA. Topical calcineurin inhibitors in atopic dermatitis: a systematic review and meta-analysis. J Dermatol Sci. 2009 May;54(2):76–87.




DOI: https://doi.org/10.29103/jkkmm.v2i5.9920

Article Metrics

 Abstract Views : 111 times
 PDF Downloaded : 5 times

Refbacks

  • There are currently no refbacks.


Copyright (c) 2023 Aji Prima Putra

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

ISSN 2830-6473 (media online)

Flag Counter

 

 

 

 

 

 

View Galenical Stats

 

 

 

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.