Penatalaksanaan Sindroma Kakeksia pada Kanker Kepala Leher
Abstract
Sindroma kakeksia (cachexia syndrome) merupakan salah satu kondisi sering dialami oleh pasien kanker kepala dan leher. Prevalensi sindroma kakeksia pada kanker kepala dan leher mencapai 80%, bahkan 20%-30% kondisi ini ditemukan pada fase sebelum pengobatan. Hal ini terjadi karena menurunnya asupan makanan oral akibat lokasi tumor yang sering menimbulkan trismus, odinofagia, disfagia, dan/atau aspirasi. Namun demikian, diagnosis dan tatalaksana sindroma kakeksia pada pasien kanker kepala leher masih sering terabaikan sehingga berpengaruh terhadap efektivitas terapi kanker serta kualitas hidup pasien. Tujuan penulisan artikel ini untuk menjelaskan tentang penatalaksanaan sindroma kakeksia pada pasien kanker kepala leher.
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Fabbro E Del, Inui A, Strasser F. Overview of cancer cachexia. In: Fabbro E Del, Inui A, Strasser F, eds. Pocket books for cancer supportive care cancer cachexia. London: Springer Healthcare Ltd; 2014. p. 1-5.
Kwon M, Kim RB, Roh J, Lee S, Kim S, Choi S, et al. Prevalence and clinical significance of cancer cachexia based on time from treatment in advanced-stage head and neck squamous cell carcinoma. Head and Neck 2016;1–8.
Jager-Wittenaar H, Dijkstra PU, Dijkstra G, Bijzet J, Langendijk JA, van der Laan BFAM, et al. High prevalence of cachexia in newly diagnosed head and neck cancer patients: An exploratory study. Nutrition 2017;35:114–8.
Richey LM, George JR, Couch ME, Kanapkey BK, Yin X, Cannon T, et al. Defining cancer cachexia in head and neck squamous cell carcinoma. Clinical Cancer Research 2007;13(22):6561–7.
Alshadwi A, Nadershah M, Carlson ER, Young LS, Burke PA, Daley BJ. Nutritional considerations for head and neck cancer patients : A review of the literature. J Oral Maxillofac Surg 2012;1–8.
Müller-richter U, Betz C, Hartmann S, Brands RC. Nutrition management for head and neck cancer patients improves clinical outcome and survival. Nutrition Research 2017;48:1–8.
Tuca A, Jimenez-Fonseca P, Gascón P. Clinical evaluation and optimal management of cancer cachexia. Crit Rev Oncol Hematol 2013;88(3)625–36.
Prevost V, Joubert C, Heutte N, Babin E. Assessment of nutritional status and quality of life in patients treated for head and neck cancer. Eur Ann Otorhinolaryngol Head Neck 2014;131(2):113–20.
Aoyagi T, Terracina KP, Raza A, Matsubara H, Takabe K. Cancer cachexia, mechanism and treatment. World J Gastrointest Oncol 2015;7(4):17-28.
Baxi SS, Schwitzer E, Jones LW. A review of weight loss and sarcopenia in patients with head and neck cancer treated with chemoradiation. Cancers of the Head and Neck 2016;1(9):1–7.
Couch ME, Dittus K, Toth MJ, Willis MS, Guttridge DC, George JR, et al. Cancer cachexia update in head and neck cancer: Definition and diagnostic features. Head Neck 2015;37(10):594–604.
Sadeghi M, Keshavarz-Fathi M, Baracos V, Arends J, Mahmoudi M, Rezaei N. Cancer cachexia: Diagnosis, assessment, and treatment. Crit Rev Oncol Hematol 2018;127:91–104.
Gorenc M, Kozjek NR, Strojan P. Malnutrition and cachexia in patients with head
and neck cancer treated with (chemo)radiotherapy. Reports Pract Oncol Radiother 2015;20(4):249–58.
Evans WJ, Morley JE, Argilés J, Bales C, Baracos V, Guttridge D, et al.Cachexia: A new definition. Clin Nutr 2008;27(6):793–9.
Orell-kotikangas H, Österlund P, Mäkitie O, Saarilahti K, Ravasco P, Schwab U, et al. Cachexia at diagnosis is associated with poor survival in head and neck cancer patients. Acta Otolaryngol 2017;1:1-9.
Takenaka Y, Takemoto N, Nakahara S, Yamamoto Y. Prognostic significance of body mass index before treatment for head and neck cancer. Head and Neck 2015;(October):1518-23.
Mcrackan TR, Watkins JM, Herrin AE, Garrett-mayer EM, Sharma AK, Day TA, et al. Effect of body mass index on chemoradiation outcomes in head and neck cancer. Laryngoscope 2008;118:1180–5.
Jacquelin-Ravel N, Pichard C. Clinical nutrition, body composition and oncology: A critical literature review of the synergies. Crit Rev Oncol Hematol 2012;84(1):37–46.
Reid J, Scott D, Santin O, Cardwell CR, Donnelly M, Kernohan WG, et al. Evaluation of a psychoeducational intervention for patients with advanced cancer who have cachexia and their lay carers (EPACaCC): Study protocol. J Adv Nurs 2014;70(5):1174–83.
Wheelwright S, Darlington AS, Hopkinson JB, Fitzsimmons D, White A, Johnson CD. A systematic review of health-related quality of life instruments in patients with cancer cachexia. Support Care Cancer 2013;21(9):2625–36.
Wheelwright SJ, Hopkinson JB, Darlington AS, Fitzsimmons DF, Fayers P, Balstad TR, et al. Development of the EORTC QLQ-CAX24, a
questionnaire for cancer patients with cachexia. J Pain Symptom Manage 2017;53(2):232–42.
Bilir C, Engin H, Can M, Temi YB, Demirtas D. The prognostic role of inflammation and hormones in patients with metastatic cancer with cachexia. Med Oncol 2015;32(3):56-61.
Mondello P, Mian M, Aloisi C, Famà F, Mondello S, Pitini V. Cancer cachexia syndrome: Pathogenesis, diagnosis, and new therapeutic options. Nutr Cancer 2015;67(1):12–26.
Hardee JP, Counts BR, Carson JA. Understanding the role of exercise in cancer cachexia therapy. Am J Lifestyle Med 2019;13(1):46–60.
Reid J. Psychosocial, educational and communicative interventions for patients with cachexia and their family carers. Curr Opin Support Palliat Care2014;8(4):334-8.
DOI: https://doi.org/10.29103/jkkmm.v3i1.14325
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