Pengaruh Berat Badan Lahir Bayi Terhadap Kejadian Hiperbilirubinemia Pada Neonatus : Systematic Literature Review
DOI:
https://doi.org/10.29103/jkkmm.v5i1.24873Keywords:
Berat Badan Lahir, hiperbilirubinemia, neonatusAbstract
Hiperbilirubinemia merupakan salah satu gangguan paling umum pada neonatus dan dapat menimbulkan komplikasi neurologis serius jika tidak ditangani dengan tepat. Berat badan lahir bayi diduga menjadi faktor determinan penting dalam risiko hiperbilirubinemia. Penelitian ini bertujuan menelaah pengaruh berat badan lahir bayi terhadap kejadian hiperbilirubinemia pada neonatus. Kajian dilakukan menggunakan pendekatan systematic literature review dengan analisis PRISMA. Pencarian literatur dilakukan melalui basis data seperti PubMed dan Google Scholar. Diperoleh 9 artikel yang memenuhi kriteria inklusi dan eksklusi untuk dianalisis lebih lanjut, dengan fokus pada perbandingan neonatus dengan berat badan lahir rendah dan normal serta mekanisme fisiologis yang mendasari hiperbilirubinemia. Hasil telaah menunjukkan bahwa BBLR memiliki kerentanan lebih tinggi terhadap hiperbilirubinemia dibandingkan bayi dengan berat badan normal. Mekanisme yang mendasari mencakup peningkatan produksi bilirubin, imaturitas fungsi hati, rendahnya kadar albumin, serta aktivitas peristaltik usus yang belum optimal. Kesimpulan penelitian ini menegaskan terdapat pengaruh yang signifikan antara berat badan lahir bayi dengan hiperbilirubinemia pada neonatus.
References
1. Kemenkes. Agar Ibu dan Bayi Selamat. Kemenkes Redaksi Sehat Negeriku [Internet]. 2024; Available from: https://sehatnegeriku.kemkes.go.id/baca/blog/20240125/3944849/agar-ibu-dan-bayi-selamat/#:~:text=Berdasarkan data dari Maternal Perinatal,pada tahun 2023 tercatat 29.945
2. Kementerian Kesehatan Republik Indonesia, Kementerian Kesehatan Republik Indonesia. Keputusan Menteri Kesehatan Republik Indonesia Nomor HK.01.07/MENKES/240/2019 Tentang Pedoman Nasional Pelayanan Kedokteran Tata Laksana Hiperbilirubinemia. Kementerian Kesehatan Republik Indonesia. 2019;1–23.
3. Kemenkes. Badan Penelitian dan Pengembangan Kesehatan. Riset Kesehatan Dasar (RISKESDAS). 2018.
4. Yasadipura CC, Suryawan IWB, Sucipta AAM. Hubungan Bayi Berat Lahir Rendah (BBLR) dengan kejadian hiperbilirubinemia pada neonatus di RSUD Wangaya, Bali, Indonesia. Intisari Sains Medis. 2020;11(3):1277–81.
5. Khotimah H, Subagio SU. Analysis of Relationship between Gestational Age, Birth Weight, Type of Childbirth and Breastfeeding with Occurrence of Hyperbilirubinemia. Faletehan Heal J [Internet]. 2021;8(2):115–21. Available from: http://journal.lppm-stikesfa.ac.id/index.php/FHJ/article/view/146
6. Pratiwi GN, Kusumaningtiar DA. Kejadian Hiperbilirubin Bayi Baru Lahir Di Rs Swasta Jakarta. J Kesmas (Kesehatan Masyarakat) Khatulistiwa. 2021;8(2):72.
7. Fathia N, Wibowo DA, Nurkholik D. Hubungan Berat Badan Bayi dengan Kejadian Hiperbilirubinemia pada Neonatus di RSUD Dr. Soekardjo Kota Tasikmalaya. J Keperawatan Galuh. 2023;5(2):113.
8. Bogale MT, Bogale WA, Kassie DG, Woldesellassie A, Tamiru AT. Factors associated with neonatal hyperbilirubinemia in case files of all admitted inborn and outborn neonates in Northwest Ethiopia in 2019. Iran J Neonatol. 2021;12(1):46–53.
9. Tessema M, Mekonnen H, Alemu T, Godie Y, Teklehaimanot WZ, Mengstie LA. Magnitude and its associated factors of neonatal jaundice among neonates admitted to the neonatal intensive care unit of Dessie Town public hospitals, Amhara region, Ethiopia, 2020: a multicenter cross-sectional study. Front Pediatr. 2024;12(January):1–8.
10. Ayalew T, Molla A, Kefale B, Alene TD, Abebe GK, Ngusie HS, et al. Factors associated with neonatal jaundice among neonates admitted at referral hospitals in northeast Ethiopia: a facility-based unmatched case-control study. BMC Pregnancy Childbirth. 2024;24(1):1–10.
11. Fanello C, Lee SJ, Bancone G, Kayembe D, Ndjowo P, Badjanga B, et al. Prevalence and Risk Factors of Neonatal Hyperbilirubinemia in a Semi-Rural Area of the Democratic Republic of Congo: A Cohort Study. Am J Trop Med Hyg. 2023;109(4):965–74.
12. Cai Y, Li X, Wang P, Song Y. Predictive factors for readmission due to neonatal hyperbilirubinemia: A retrospective case-control study. PLoS One [Internet]. 2025;20(4 April):1–8. Available from: https://doi.org/10.1371/journal.pone.0320767
13. Armatheina PF, Suryawan IWB, Indrawan IGDK. Hubungan Bayi Berat Lahir Rendah dengan Kejadian Hiperbilirubinemia di Rumah Sakit Umum Daerah Wangaya Kota Denpasar. Sari Pediatr. 2023;25(1):15.
14. Huo Y, Peng C, Hou X, Feng Q. Clinical practice guideline revision: management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Chinese J Neonatol. 2023;38(09):513–24.
15. Stevenson DK, Bhutani VK. Neonatal Hyperbilirubinemia in Preterm Neonates. Clin Perinatol [Internet]. 2016;43(2):i. Available from: http://dx.doi.org/10.1016/S0095-5108(16)30015-X
16. Amin SB. Bilirubin Binding Capacity in the Preterm Neonate. Clin Perinatol. 2017;176(10):139–48.
17. Jayanti S, Ghersi-Egea JF, Strazielle N, Tiribelli C, Gazzin S. Severe neonatal hyperbilirubinemia and the brain: The old but still evolving story. Pediatr Med. 2021;4:0–3.
18. American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2022 Jul;114(1):297–316.
19. BPS Indonesia, S.I. (2023) ‘Catalog : 1101001’, Statistik Indonesia 2023 [Preprint]. Available at: https://www.bps.go.id/publication/2020/04/29/e9011b3155d45d70823c141f/statistik-indonesia-2020.html.
20. Gemilastari, R. et al. (2024) ‘Karakteristik Bayi Dengan Berat Badan Lahir Rendah (BBLR)’, Scientific Journal, 3(1), pp. 16–26. Available at: https://doi.org/10.56260/sciena.v3i1.125.
21. Kamal, M.F.F. (2024) ‘Hiperbilirubinemia’, GALENICAL: Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Vol.3, 3(6), pp. 90–101.
22. Kemenkes (2018) ‘Badan Penelitian dan Pengembangan Kesehatan. Riset Kesehatan Dasar (RISKESDAS)’.
23. Kemenkes (2019) ‘Tata Laksana Perawatan Bayi Berat Badan Lahir Rendah (BBLR)’, Kemenkes RSUP Dr. Sardjito Yogyakarta [Preprint]. Available at: https://sardjito.co.id/2019/06/03/tata-laksana-perawatan-bayi-berat-badan-lahir-rendah-bblr/.
24. Kemenkes (2023) ‘Pengkajian dan Pemeriksaan Fisik pada Bayi Baru Lahir’, Kemenkes, Direktorat Jenderal Kesehatan Lanjutan [Preprint]. Available at: https://keslan.kemkes.go.id/view_artikel/2763/pengkajian-dan-pemeriksaan-fisik-pada-bayi-baru-lahir.
25. Mathindas, S., Wilar, R. and Wahani, A. (2017) ‘Hiperbilirubinemia Pada Neonatus’, Jurnal Biomedik (Jbm), 5(1). Available at: https://doi.org/10.35790/jbm.5.1.2013.2599.
26. Rohsiswatmo, R. and Amandito, R. (2018) ‘Hiperbilirubinemia pada neonatus >35 minggu di Indonesia; pemeriksaan dan tatalaksana terkini’, Sari Pediatri, 20(2), p. 115. Available at: https://doi.org/10.14238/sp20.2.2018.115-22.
27. Suprihatini, M., Murniasih, E. and Eliawati, U. (2023) ‘Faktor-Faktor Yang Berhubungan Dengan Kejadian Hiperbilirubinemia Pada Bayi Di Ruang Perinatologi RSUD Kota Tanjungpinang’, An-Najat, 1(4), pp. 96–107. Available at: https://jurnal.stikes-ibnusina.ac.id/index.php/an-Najat/article/view/516.
28. Widayanti, D. (2020) ‘Karakteristik Ibu Dengan Bayi Berat Lahir Rendah Di Rsud Wonosari Tahun 2020 Karakteristik Ibu Dengan Bayi Berat Lahir Rendah Di Rsud Wonosari Tahun 2020’, Paper Knowledge . Toward a Media History of Documents, 3(2), p. 6.
29. Windiyanto, R. and Armerinayanti, N.W. (2024) ‘Karakteristik Pencetus Hiperbilirubinemia pada Neonatus di Rumah Sakit Daerah Mangusada Badung Bali Rumah Sakit Umum Pusat Sanglah terdapat’, e-Journal AMJ (Aesculapius Medical Journal), 4(3), pp. 303–312.
30. World Health Organization (2019) ‘Preterm and low birth weight infants’. Available at: https://www.who.int/teams/maternal-newborn-child-adolescent-health-and-ageing/newborn-health/preterm-and-low-birth-weight.
31. Wulan Nur Insani, Erni Saraswati (2016) ‘Faktor-Faktor Yang Berhubungan Dengan Kejadian Bayi Berat Lahir Rendah Di Rsu Daerah Kabupaten Sumedang Periode Tahun 2016’, Jurnal Stikes Respati [Preprint].
32. Yekti Widadi, S. et al. (2023) ‘Hubungan Berat Badan Lahir Rendah dengan Kejadian Hiperbilirubin di Ruang Perinatologi RSUD dr. Slamet Garut’, Syntax Literate ; Jurnal Ilmiah Indonesia, 8(2), pp. 1600–1612. Available at: https://doi.org/10.36418/syntax-literate.v8i2.11458.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Ni Luh Putu Mahadewi Eka Putri Prayogo, I Made Kusuma Wijaya, Made Suadnyani Pasek
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
COPYRIGHT NOTICE
Authors retain copyright and grant the journal right of first publication and this work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
All articles in this journal may be disseminated by listing valid sources and the title of the article should not be omitted. The content of the article is liable to the author.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
In the dissemination of articles, the author must declare the GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh as the first party to publish the article.
