Kanker Serviks

Vera Novalia

Abstract


Kanker serviks merupakan penyakit yang sering terjadi pada wanita di dunia maupun di Indonesia. Kanker serviks menduduki urutan keempat di dunia sedangkan Indonesia menduduki urutan kedua. Menurut data Globocan tahun 2020 penderita kanker serviks meningkat 36.633 (17,2%) dengan jumlah kematian  234.51. Kanker serviks terjadi karena adanya infeksi virus HPV viral onkogen yaitu E6 dan E7. Serta faktor lainnya seperti paparan zat mutagen adalah faktor hormonal, merokok, berganti-ganti pasangan seksual dan konstrasepsi. Perlu dilakukan terapi pada penderita kanker serviks yaitu dengan pemberian vaksin, deteksi dini (Pap smear dan Inspeksi Visual dengan Asam Asetat), Radioterapi (RT) dengan Akselerator linear (Linear Accelerator, LINAC) dan anti VEGF (Vascular Endothelial Growth Factor) berperan penting dalam mengontrol pertumbuhan tumor dan metastasis.


Keywords


Kanker serviks, HPV, patogenesis

Full Text:

PDF

References


Halim, A. R., dan Khayati, N. 2020. Pengaruh Hypnotherapy Lima Jari terhadap Penurunan Intensitas Nyeri pada Pasien Kanker Serviks. Ners Muda.

Kementerian Kesehatan Republik Indonesia. 2017. Pedoman Nasional Pelayanan Kedokteran Kanker Serviks. Jakarta; Kementerian Kesehatan Republik Indonesia;

Globocan. Cancer Today. World Health Organization. 2012. Lyon: World Health Organization; Available from:https://gco.iarc.fr/today/factsheets-populations.

Low E L, Alice E S, Lyons J, Debbie R A, Waller J. 2012. What do British Women Know About Cervical Cancer Symptomsand Risk Factors? European Journal of Cancer 48 : 3001-3008.

Ibeanu, Okechukwu A. 2011. Molecular Pathogenesis of Cervical Cancer Division of Gynecologic Oncology. Post-Doctoral Fellow; Johns Hopkins University; Baltimore, MD. USA Cancer Biology & Therapy journal. 11: 295-306.

Antara, H., 2015. Pencegahan, S., Serviks, K., Minat, D., Dini, D., Inspeksi, M., Asam, V., Pada, A., & Usia, W. 11 (96): 102–116.

Markowitz. L, E. Hariri, S. Caron L. Eileen F. D, Steinau M. Geraldine M, and Elizabeth R. U. 2013. Reduction in Human Papillomavirus (HPV) Prevalence Among YoungWomen Following HPV Vaccine Introduction in the United States, National Health and Nutrition Examination Surveys, 2003–2010 The Journal of Infectious Diseases. Published by Oxford University Press on behalf of the Infectious Diseases Society of America 1-9.

Low E L, Alice E S, Lyons J, Debbie R A, Waller J. 2012. What Do British Women Know About Cervical Cancer Symptomsand Risk Factors? European Journal of Cancer 48 : 3001-3008.

Alba, A M C and Rodriquez C C. 2009. The Human Papillomavirus (HPV) in Human Pathology Description, Pathogenesis, Oncogenic Role, Epidemiology and Detection Techniques. The Open Dermatology Journal. Volume 3 : 90-102.

Araldi RP, Sant'Ana TA, Modolo DG, de Melo TC, Spadacci-Morena DD, de Cassia Stocco R, et al. The Human Papillomavirus (HPV)-Related Cancer Biology: An Overview. Biomedicine & Pharmacotherapy. 2018;106:1537-56.

WHO. 2014. Comprehensive Cervical Cancer Control: A Guide to Essential Practice. Geneva, Switzerland: WHO

Pattyn J, Van Keer S, Tjalma W, Matheeussen V, Van Damme P, Vorsters A. Infection and Vaccineinduced HPV-Specific Antibodies in Cervicovaginal Secretions. A Review of the Literature. Papillomavirus Research. 2019;8:100185.

Khorasanizadeh, F. Jaleh H. Nafiseh K. Somayeh M T, Maryam M, Batool H. R., Ali A. S. Kazem Z. 2012. Epidemiology of Cervical Cancer and Human Papilloma Virus Infection Among Iranian Women — Analyses of National Data and Systematic of The Literature. Gynecologic Oncology 128 : 277–281.

Marliana, Y. 2014. Akurasi Metode Inspeksi Visual dengan Asam Asetat/Iva untuk Deteksi Dini Kanker Leher Rahim. Jurnal Kesehatan Prima. 8(2): 1336-1344

Juanda, D dan Kesuma, H. 2015. Pemeriksaan Metode IVA (Inspeksi Visual Asam Asetat) untuk Pencegahan Kanker Serviks. Jurnal Kedokteran dan Kesehatan, 2(2): 169-174

Winarno, Nurmansya, V. A, Miskiyah, Z. 2021. Radioterapi Kanker Cervix dengan Linear Accelerator (Linac). Jurnal Biosains Pascasarjana Vol. 23(2): 75-77

Perrelli F, Agostina D S, Francesco R, Domenica L, Sandro B. 2014. Radiotherapy with Concurrent Cisplatin-Based Doublet or Weekly Cisplatin for Cervical Cancer: A Systematic Review and Meta-Analysis. Gynecologic Oncology 134 : 166–171.




DOI: https://doi.org/10.29103/jkkmm.v2i1.10134

Article Metrics

 Abstract Views : 9189 times
 PDF Downloaded : 1719 times

Refbacks

  • There are currently no refbacks.


Copyright (c) 2023 Vera Novalia

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

ISSN 2830-6473 (media online)

Flag Counter

 

 

 

 

 

 

View Galenical Stats

 

 

 

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.