Association Between Obstructive Sleep Apnea Symptoms and Quality of Life in Chronic Obstructive Pulmonary Disease Patients
DOI:
https://doi.org/10.29103/averrous.v12i1.27094Keywords:
Chronic Obstructive Pulmonary Disease, Ostructive Sleep Apnea, quality of lifeAbstract
Chronic Obstructive Pulmonary Disease (COPD) is one of the leading causes of mortality worldwide, frequently associated with sleep disturbances, including obstructive sleep apnea (OSA), which may negatively affect patients’ quality of life. This study aimed to describe the demographic characteristics of COPD patients, assess the severity of OSA symptoms and health-related quality of life, and analyze the association between OSA symptoms and quality of life in COPD patients. This quantitative study used a cross-sectional correlational design and was conducted in the Pulmonology Department of Prof.Chairuddin Panusunan Lubis Hospital. A total of 96 COPD patients were recruited using convenience sampling, with inclusion and exclusion criteria. Data were analyzed using univariate and bivariate analyses with the chi-square test at a significance level of α = 0.05. The results demonstrated a significant association between OSA symptoms and health-related quality of life in COPD patients (p = 0.012). Patients with moderate-to-high OSA risk were 2.97 times more likely to experience impaired quality of life compared with those at low risk (OR = 2.97; 95% CI: 1.09–8.09). These findings suggest that OSA symptoms may contribute to reduced quality of life in COPD patients and highlight the importance of early screening and comprehensive management of sleep-related disorders in clinical practice.
References
1. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for prevention, diagnosis and management of COPD: 2026 report [Internet]. GOLD; 2026 [cited 2026 May 11]. Available from: GOLD 2026 Report
2. Kim SJ, Kwak N, Choi SM, Lee J, Park YS, Lee CH, et al. Sleep duration and its associations with mortality and quality of life in chronic obstructive pulmonary disease: results from the 2007–2015 KNHANES. Respiration. 2021;100(11):1043-1049. https://doi.org/10.1159/000516381
3. Slowik JM, Sankari A, Collen JF. Obstructive sleep apnea. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 [cited 2026 May 11]. Available from: StatPearls OSA
4. Sunwoo BY, Raphelson JR, Malhotra A. Chronic obstructive pulmonary disease and obstructive sleep apnea overlap: who to treat and how? Expert Rev Respir Med. 2024;18(7):527-537. https://doi.org/10.1080/17476348.2024.2384036
5. World Health Organization. Chronic obstructive pulmonary disease (COPD) [Internet]. WHO; 2023 [cited 2026 May 11]. Available from: WHO COPD Fact Sheet
6. Papaioannou AI, Fouka E, Nena E, Bakakos P, Steiropoulos P. Patient-reported outcome measurements in patients with COPD-obstructive sleep apnea overlap syndrome: time for action? J Pers Med. 2022;12(12):1951. https://doi.org/10.3390/jpm12121951
7. Fanaridis M, Bouloukaki I, Stathakis G, Steiropoulos P, Tzanakis N, Moniaki V, et al. Prevalence and characteristics of patients with obstructive sleep apnea and chronic obstructive pulmonary disease: overlap syndrome. Life (Basel). 2024;14(5):547. https://doi.org/10.3390/life14050547
8. Van Zeller M, Basoglu OK, Verbraecken J, Lombardi C, McNicholas WT, Pepin JL, et al. Sleep and cardiometabolic comorbidities in the obstructive sleep apnoea-COPD overlap syndrome: data from the European Sleep Apnoea Database. ERJ Open Res. 2023;9(3):00676-2022. https://doi.org/10.1183/23120541.00676-2022
9. Srivali N, Thongprayoon C, Tangpanithandee S, Cheungpasitporn W, Won C. The use of continuous positive airway pressure in COPD-OSA overlap syndrome: a systematic review. Sleep Med. 2023;108:55-60. https://doi.org/10.1016/j.sleep.2023.05.025
10. Dudek M, Szymanski FM, Piekarska A, et al. The overlap syndrome of obstructive sleep apnea and chronic obstructive pulmonary disease: a systematic review. Biomedicines. 2023;11(1):16. https://doi.org/10.3390/biomedicines11010016
11. Liu M, Yang X, Wang Y, Lu Y, Liang L, Zhang H, et al. Comparison of health-related quality of life measures in asthma-COPD overlap. Chron Respir Dis. 2023;20:14799731231215093. https://doi.org/10.1177/14799731231215093
12. Voulgaris A, Gogali A, Kostikas K, Steiropoulos P. Management of COPD-OSA overlap syndrome beyond standard care. COPD. 2026;23(1):2599583. https://doi.org/10.1080/15412555.2025.259958
13. Locke BW, Lee JJ, Sundar KM. OSA and chronic respiratory disease: mechanisms and epidemiology. Int J Environ Res Public Health. 2022;19(9):5478.
14. Abbasi A, Gupta SS, Sabharwal N, et al. A comprehensive review of obstructive sleep apnea. Sleep Sci. 2021;14(2):142-54. doi:10.5935/1984-0063.20200056.
15. Sunwoo BY, Raphelson JR, Malhotra A. Chronic obstructive pulmonary disease and obstructive sleep apnea overlap: who to treat and how? Expert Rev Respir Med. 2024;18(7):527-37. doi:10.1080/17476348.2024.2384036.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Muhammad Khoir Gultom, Andika Pradana, Amira Permatasari Tarigan

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors retain copyright and grant the journal right of first publication and this work is licensed under a Creative Commons Attribution-ShareAlike 4.0 that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
All articles in this journal may be disseminated by listing valid sources and the title of the article should not be omitted. The content of the article is liable to the author.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
In the dissemination of articles, the author must declare the AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Journal as the first party to publish the article.











