Factors Associated with Acceptance of Tuberculosis Preventive Therapy Among Household Contacts in Lhokseumawe

Authors

  • Hendra Wahyuni Faculty of Medicine, Universitas Malikussaleh
  • Rizka Sofia Faculty of Medicine, Universitas Malikussaleh,
  • Anugrah A Warid Rambe Universitas Malikussaleh

DOI:

https://doi.org/10.29103/averrous.v12i1.26792

Keywords:

Household contacts, pulmonary tuberculosis, TB preventive therapy, tuberculin skin test, TPT acceptance

Abstract

Household contacts of tuberculosis (TB) patients are among the groups at highest risk of contracting TB, a condition preventable through Tuberculosis Preventive Therapy (TPT). This study aimed to identify factors associated with TPT acceptance among household contacts of pulmonary TB patients at public health centers in Lhokseumawe City. An analytical observational study with a cross-sectional design was conducted involving 139 household contacts of pulmonary TB patients. Subjects were recruited based on predefined inclusion and exclusion criteria. Data were collected using a structured questionnaire and analyzed using Fisher's exact test at a significance level of 0.05. The history of tuberculin skin test (TST) examination was the only variable significantly associated with TPT acceptance (p = 0.048). No significant associations were found for age, sex, education level, relationship to the TB patient, knowledge level, distance from health center, or receipt of TPT education. A total of 137 of 139 respondents (98.6%) refused TPT, reflecting a critically low acceptance rate that demands programmatic attention. Intensification of TST-integrated contact investigation and more targeted counseling approaches are recommended to improve TPT uptake.

Author Biographies

Hendra Wahyuni, Faculty of Medicine, Universitas Malikussaleh

Department of Public Health, Faculty of Medicine, Universitas Malikussaleh, Aceh, Indonesia

Rizka Sofia, Faculty of Medicine, Universitas Malikussaleh,

Department of Parasitology, Faculty of Medicine, Universitas Malikussaleh, Aceh, Indonesia

Anugrah A Warid Rambe, Universitas Malikussaleh

Kedokteran, Fakultas Kedokteran

References

1. World Health Organization. Global Tuberculosis Report 2023. Geneva: World Health Organization; 2023.

2. Sulistyo, Utami ASF, Wicaksono AB, Khalishah AD. Laporan program penanggulangan tuberkulosis tahun 2022. Kemenkes RI. 2023;1:1-77.

3. Sari RM. Hubungan antara karakteristik kontak dengan adanya gejala TB pada kontak penderita TB paru BTA positif. J Berk Epidemiol. 2014;2(2):274-85.

4. Zara N, Septina V, Wahyuni H. Upaya pengelolaan TB paru dan underweight dengan pendekatan pelayanan dokter keluarga. Galen J Kedokt Kesehat Mhs Malikussaleh. 2023;2(1):88-104.

5. Safitri IN, Martini M, Adi MS, Wurjanto MA. Faktor yang berhubungan dengan penerimaan terapi pencegahan TB di Kabupaten Tegal. J Ris Kesehat Masy. 2023;3(4):212-20.

6. Machavariani E, Nonyane BAS, Lebina L, Mmolawa L, West NS, Dowdy DW, et al. Perceived stigma among people with TB and household contacts. Int J Tuberc Lung Dis. 2023;27(9):675-81. doi:10.5588/ijtld. 22.0670.

7. Courtwright A, Turner AN. Tuberculosis and stigmatization: Pathways and interventions. Public Health Rep. 2010;125(Suppl 4):34-42.

8. Sterling TR, Njie G, Zenner D, Cohn DL, Reves R, Ahmed A, et al. Guidelines for the treatment of latent tuberculosis infection: Recommendations from the National Tuberculosis Controllers Association and CDC, 2020. MMWR Recomm Rep. 2020;69(1):1-11.

9. World Health Organization. WHO Consolidated Guidelines on Tuberculosis. Module 1: Prevention - Tuberculosis Preventive Treatment, Second Edition. Geneva: World Health Organization; 2024.

10. Indonesian Health Literacy Journal. Terapi pencegahan tuberkulosis dan investigasi kontak di Indonesia. IHLJ. 2025;2(2):76.

11. Martini M, van de Berg MJJMM, Patel PD, Nababan HY, Siregar AYM, Mahendradhata Y, et al. High tuberculosis preventive treatment uptake and completion rates using a person-centered approach among tuberculosis household contacts in Yogyakarta. Trop Med Infect Dis. 2023;8(12):520. doi:10.3390/tropicalmed8120520.

12. Adjobimey M, Trajman A, Bastos ML, Valiquette C, Gibson D, Djohoun F, et al. Rapid molecular testing or chest X-ray or tuberculin skin testing for household contact assessment of tuberculosis infection: a cluster-randomized trial. PLoS Med. 2025;22(7):e1004666. doi:10.1371/journal.pmed.1004666.

13. Safitri IN, Martini M, Adi MS, Wurjanto MA. Faktor yang berhubungan dengan penerimaan terapi pencegahan TB di Kabupaten Tegal. J Ris Kesehat Masy. 2023;3(4):212-20.

14. Mukhayah S. Faktor-faktor yang berhubungan dengan penerimaan terapi pencegahan tuberkulosis (TPT) pada kontak serumah penderita tuberkulosis di Kabupaten Mesuji tahun 2023-2024. J Poltekkes Tanjung Karang. 2024;1(1):34-9.

15. Bhatt NB, den Boon S, Subramanian AK, Yuen CM, Dossing M. Preventive treatment for household contacts of drug-susceptible tuberculosis patients. Pathogens. 2022;11(11):1354. doi:10.3390/pathogens11111354.

16. Maranatha A, Duduong V, Fretes F De, Nakka D. Pengetahuan pencegahan tuberkulosis paru dalam keluarga. J Hum Heal. 2024;3(2):1-10.

17. Mohamad Ridwan. Hubungan tingkat pengetahuan dan sikap dengan perilaku pencegahan penularan tuberkulosis di wilayah kerja Puskesmas Ngemplak, Kabupaten Boyolali. Electron These Diss Univ Muhammadiyah Surakarta. 2015.

18. Wang N, Wu L, Liu Z, Liu J, Liu X, Feng Y, et al. Influence of tuberculosis knowledge on acceptance of preventive treatment and the moderating role of tuberculosis stigma among China's general population: cross-sectional analysis. BMC Public Health. 2024;24(1). doi:10.1186/s12889-024-18482-3.

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Published

2026-05-27

Issue

Averrous, Volume 12 No.1 Mei 2026

Section

Articles

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Copyright (c) 2026 Hendra Wahyuni, Rizka Sofia, Anugrah A Warid Rambe

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